HHU StartMNFBiologySynthetic Microbiology
Deconvolved fluorescence microscopy image of Synechocystis sp. PCC6803 wild-type cells (red, autofluorescence from Synechocystis; blue, Hoechst-stained DNA)
Synechocystis sp. PCC6803 wild-type cells

Welcome to the Institute of Synthetic Microbiology

The Institute for Synthetic Microbiology researches molecular regulatory processes in microorganisms influenced by internal factors like small RNA molecules, the circadian clock, and supercoiling of DNA. Learning from the plethora of regulatory mechanisms, we design and test e.g. synthetic RNA switches, heterologous metabolic pathways, and biosensors. By implementing these parts and devices into microorganisms, we are aiming at a smart, automated, and dynamic control of signaling and metabolic pathways. Particular focus is placed on the engineering of Cyanobacteria as future hosts for a sustainable biotechnology.


13.06.2019 Graduation | Nic and Beate

We are very proud of our new graduates Dr. Beate Heilmann and Dr. Nicolas Schmelling, who is also our first official SynMiBi PhD graduate at Heinrich-Heine-University Düsseldorf. Congratulations!

27.05.2019 Guest | Elke Dittmann

Today we invited Elke Dittmann (undefined Department of Microbiology, University of Potsdam) to give a talk and present her latest research on the different faces of RuBisCO in the bloom-forming cyanobacterium Microcystis aeruginosa, in the Plant Biology Seminar Series.

17. - 20.03.2019 Annual Conference 2019 of the Association for General and Applied Microbiology (VAAM) in Mainz

We are back from the very interesting annual conference of the undefinedVAAM in Mainz. Our new PhD student Anna Germann and our former Bachelor student Sebastian Triesch presented their results on "Model-based pathway engineering towards optimized heterologous triterpene production in Synechocystis sp. PCC 6803" from last year at the poster session. In addition, our PhD students Anna Behle and Maximilian Dietsch represented our group with their oral presentations on "New gene regulatory tools to improve synthetic biology in Synechocystis sp. PCC 6803" and "DNA topology in Synechocystis sp. PCC6803", respectively. We look forward to the young investigator conference “Cyano 2019” in Tübingen and a reunion with familiar faces in autumn!

14.02.2019 Guest | Toby Warnecke

Today we invited Toby Warnecke (undefinedMRC London) to give a talk and present his latest research findings on the evolutionary origin of histone-based chromatin organisation, in the Theory Seminar Series.

7.02.2019  SynMiBi moves to ZSL

Today our Institute of Synthetic Microbiology is taking a big step moving to our brand-new Center for Synthetic Life Sciences - ZSL - The Riesner Building.

10.01.2019 Guest | Sven Findeiß

Today we invited Sven Findeiß (undefinedInstitute of Computer Science, Bioinformatics Group, University of Leipzig) to give a talk and present his latest research findings in the Theory Seminar Series. He is giving an overview on methods for rational de novo design of multi-stable RNA molecules and their applications.

02.10.2018 Visit to Algenol Biotech in Florida

Our PhD students Anna and Max visited the laboratories and facilities of undefinedAlgenol Biotech in Ft. Myers, Florida, where cyanobacteria and algae are manipulated, grown and maintained at large volumes. They gained many interesting insights into the biotech industry.

24. - 28.10.2018 iGEM Team | Giant Jamboree in Boston

Our PhD students Anna and Max, who were advisors of this year’s iGEM team, attended the Giant Jamboree in Boston. The team, who worked on a synthetic co-culture toolbox for almost a year, won a gold medal and was nominated for Best Basic Part. Congratulations!

22. - 24.10.2018 Interdisciplinary Origin of Life Meeting

Rainer and Nic will give talks about projects related to evolution of circadian clocks and the impacts of mobile elements at the first Interdisciplinary Origin of Life Meeting here in Düsseldorf.

17. - 20.10.2018 EMBO Workshop - Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems

Our PostDoc Rainer is preseting results of his work at the EMBO workshop on a poster with the title "Chemostat Oscillations, Growth Laws & Evolution: Experimental Transcription of Proto-Genes during the Low Energy Phase"

12. - 14.09.2018 16th conference on Computational Methods in Systems Biology (CMSB 2018) in Brno, Czech Republic

Ilka Axmann gave an invited talk at CMSB 2018 at the Mendel Museum in Brno on modeling the cyanobacterial clock, supported by the National Infrastructure for Systems Biology.

12. - 14.09.2018 Cyano2018

Our PhD students Anna, Max and Nic as well as member of this year's iGEM Team presented their work at the 3rd Early Career Research Symposium on Cyanobacteria in Freiburg.

15.06.2018 Press Conference by AGRIVIZION

Rudolf Cordes (undefinedNovaGreen) and Ilka Maria Axmann (Institute of Synthetic Microbiology) are talking about microalgae as renewable resources for phytopharmaceuticals. Read more about the press conference undefinedhere.

14.06.2018 Guest | Andreas Angermayr

Today we invited Andreas Angermayr (undefinedInstitute for Biological Physics, University of Cologne) to give a talk and present his latest research findings in the Theory Seminar Series. He is giving an overview about the sensitivity of bacteria to antibiotics and how a growth-mediated negative feedback loop lowers this sensitivity.

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